来自瑞典的Acedo P和Zawacka-Pankau J.(卡罗琳斯卡医学院，肿瘤和细胞生物学，微生物部)近期发表名为"p53 family members – important messengers in cell death signaling in photodynamic therapy of cancer? "的文章，表示p53家族在光动治疗肿瘤而杀死细胞的过程中可能发挥重要作用。
TP53 is one of the genes most frequently inactivated in cancers.Mutations in TP53 gene are linked to worse prognosis and shorter overall survival of cancer patients. TP53 encodes a critical tumor suppressor, which dictates cell fate decisions upon stress stimuli. As a sensor of cellular stress, p53 is a relevant messenger of cell death signaling in ROS-driven photodynamic therapy (PDT) of cancer. The significant role of p53 in response to PDT has been reported for several clinically approved photosensitizers. Multiple reports described that wild-type p53 contributes to cell killing upon photodynamic therapy with clinically approved photosensitizers but the mechanism is still not fully understood. This work outlines the diverse functions of p53 family members in cancer cells’ susceptibility and resistance to PDT. In summary p53 and p53 family members are emerging as important mediators of cell death signaling in photodynamic therapy of cancer, however the mechanism of cell death provoked during PDT might differ depending on the tissue type and the photosensitizer applied.
PMID: 26202022 [PubMed – as supplied by publisher]
Photochem Photobiol Sci. 2015 Jul 23.