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P53家族是光动力治疗肿瘤导致细胞死亡的信使?

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 来自瑞典的Acedo PZawacka-Pankau J.(卡罗琳斯卡医学院,肿瘤和细胞生物学,微生物部)近期发表名为"p53 family members – important messengers in cell death signaling in photodynamic therapy of cancer? "的文章,表示p53家族在光动治疗肿瘤而杀死细胞的过程中可能发挥重要作用

 

摘要

TP53 是肿瘤中最常见的抑癌基因之一。TP53基因突变可能导致肿瘤病人的预后更差以及生存期更短。TP53编码一个环状的肿瘤抑癌基因,它通过应激刺激决定细胞的命运。作为一个细胞应激传感器,p53是活性氧驱动的光动力治疗肿瘤中细胞死亡信号系统的一个重要信使。几种光敏剂的临床批准报道了p53响应PDT的重要作用。许多报道称:用临床批准的光敏剂进行光动力治疗中野生型p53会导致细胞的死亡,但是其机制目前还没有完全明确。该文章概括了在肿瘤细胞敏感性和抵抗PDT方面p53家族的不同功能。总之,p53p53家族作为光动力治疗肿瘤中细胞死亡信号传递的重要介质正在浮出水面,然而,光动力治疗中细胞死亡的机制可能因组织类型和应用光敏剂的不同而异。


Abstract

TP53 is one of the genes most frequently inactivated in cancers.Mutations in TP53 gene are linked to worse prognosis and shorter overall survival of cancer patients. TP53 encodes a critical tumor suppressor, which dictates cell fate decisions upon stress stimuli. As a sensor of cellular stress, p53 is a relevant messenger of cell death signaling in ROS-driven photodynamic therapy (PDT) of cancer. The significant role of p53 in response to PDT has been reported for several clinically approved photosensitizers. Multiple reports described that wild-type p53 contributes to cell killing upon photodynamic therapy with clinically approved photosensitizers but the mechanism is still not fully understood. This work outlines the diverse functions of p53 family members in cancer cells’ susceptibility and resistance to PDT. In summary p53 and p53 family members are emerging as important mediators of cell death signaling in photodynamic therapy of cancer, however the mechanism of cell death provoked during PDT might differ depending on the tissue type and the photosensitizer applied.

 

PMID: 26202022 [PubMed – as supplied by publisher]

 

Photochem Photobiol Sci. 2015 Jul 23.


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