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固定/游离巨噬细胞对光动力影响大肠癌微环境的贡献

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 阿根廷学者在Tumour Bio( 2015 Aug 1版)发表论文称不同形态的巨噬细胞对光动力治疗肿瘤的效应有影响,因此他们提出在总体设计抗肿瘤方案时需要考虑到不同形态巨噬细胞的影响因素


具体摘要信息如下:

 

 

研究肿瘤微环境中分子的相互作用已经成为一个主要的抗肿瘤研究领域。肿瘤相关的巨噬细胞因其功能可塑性影响肿瘤增值和治疗效应。关于肿瘤治疗,光动力疗法是一种攻击性小且临床批准的治疗方法,其涉及到光敏剂的管理,光敏剂是一种光敏毒性药物,选择性的续集在肿瘤组织中。


这里,我们通过开发2-D和3-D 相结合的试验性平台在体外再创造肿瘤-间质相互作用来研究固定巨噬细胞和游离巨噬细胞在光动力治疗大肠癌中的作用。在游离巨噬细胞存在的情况下增强了PDT的细胞毒性,通过表面介导产生一氧化氮,IL-6 和肿瘤坏死因子TNF-α而具有强的抗肿瘤效应。相反,肿瘤固定巨噬细胞包含一种促癌表型促进肿瘤细胞的转移和内皮刺激。


由于它们的可塑性,固定肿瘤和游离肿瘤的巨噬细胞可以对PDT治疗肿瘤有不同的影响,因此在总体设计抗肿瘤治疗方案中需要考虑它们的多因素作用。

 

Abstract

The study of cellular interactions in the tumor microenvironment has become one of the main areas of research in the fight against cancer. Tumor-associated macrophages (TAMs) influence tumor progression and therapy response due to its functional plasticity. Regarding cancer treatment, photodynamic therapy (PDT) is a minimally invasive and clinically approved procedure that involves the administration of a photosensitizer (PS), a nontoxic photosensitizing drug which is selectively retained in neoplastic tissue.

 

Here, we investigated the role of resident and nonresident macrophages in the context of a PDT-treated colorectal tumor by developing a combination of 2-D and three-dimensional (3-D) experimental platform, recreating tumor-stroma interactions in vitro.Enhancement of cytotoxicity of PDT was achieved in the presence of nonresident macrophages which had a strong anti-tumor phenotype mediated by the production of nitric oxide, IL-6, and tumor necrosis factor alpha (TNF-α). On the contrary, tumor resident macrophages induced a pro-tumor phenotype promoting tumor cell migration and endothelial stimulation.

 

Due to their plasticity, tumor-resident or tumor-recruited macrophages can differentially influence the response of tumors to PDT, so their multifactorial roles should be considered in the overall design of anti-tumor therapeutic.


深圳微创译自:

 

Tumour Biol. 2015 Aug 1.

Contribution of resident and recruited macrophages to the photodynamic intervention of colorectal tumor microenvironment.


Author information

Pansa MF1, Lamberti MJ, Cogno IS, Correa SG, Rumie Vittar NB, Rivarola VA.

1Departamento de Biología Molecular, Facultad de Ciencias Exactas Físico-Químicas y Naturales, Universidad Nacional de Río Cuarto, 5800, Río Cuarto, Córdoba, Argentina.



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